Remote Ultrasonic Neuromodulation

Dr. William J. Tyler is an Assistant Professor in the School of Life Sciences at Arizona State University, is a co-founder and the CSO of SynSonix, Inc., and a member of the 2010 DARPA Young Faculty Award class.

neuro modulationEvery single aspect of human sensation, perception, emotion, and behavior is regulated by brain activity. Thus, having the ability to stimulate brain function is a powerful technology.

Recent advances in neurotechnology have shown that brain stimulation is capable of treating neurological diseases and brain injury, as well as serving platforms around which brain-computer interfaces can be built for various purposes. Several limitations however still pose significant challenges to implementing traditional brain stimulation methods for treating diseases and controlling information processing in brain circuits.

For example, deep-brain stimulating (DBS) electrodes used to treat movement disorders such as Parkinson’s disease require neurosurgery in order to implant electrodes and batteries into patients. Transcranial magnetic stimulation (TMS) used to treat drug-resistant depression and other disorders do not require surgery, but have a low spatial resolution of approximately one centimeter and cannot stimulate deep brain circuits where many diseased circuits reside.

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A portion of our initial work has been supported by the U.S. Army Research, Development and Engineering Command (RDECOM) Army Research Laboratory (ARL) where we have been working to develop methods for encoding sensory data onto the cortex using pulsed ultrasound.

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