Oxytocin Spray Keeps them Trusting

Spray said to turn people into pushovers

Imagine all the possible implications of this technology, i.e., keeping the populace trusting in its government.

Re­search­ers have iden­ti­fied brain cen­ters acti­vated by be­tray­al of trust—and a way to keep them quiet.

A spray of a oxytocin, a hormone, makes peo­ple keep trust­ing even some­one who has be­trayed them, the scientists ex­plained. They presented the findings not as a trick for, say, cheat­ing spouses to keep their part­ners coop­erative, but as an in­sight into the mind with possible cli­ni­cal value.

Thom­as Baum­gart­ner of the Uni­ver­s­ity of Zu­rich and col­leagues said their work could help re­veal the brain wir­ing be­hind trust and pos­sibly the ba­sis of so­cial dis­or­ders such as pho­bias and au­tism. The find­ings are re­ported in the May 22 is­sue of the re­search jour­nal Neu­ron.

Amygdala activation, shown in red in a cross-sec­tion of the brain in an fMRI image. (Cou­rtesy NIMH Cli­n­i­cal Brain Dis­ord­ers Branch)
The in­ves­ti­ga­tors asked vol­un­teers to play a “trust game” in which they con­tri­but­ed mon­ey to a hu­man trus­tee, who would ei­ther in­vest it and re­turn the prof­it­s—or be­tray them and keep it all.

Some play­ers al­so re­ceived a na­sal spray con­tain­ing the brain chem­i­cal and hor­mon ox­y­to­cin, found in pre­vi­ous stud­ies to make peo­ple more trust­ing.

The re­search­ers found that stiffed play­ers who had re­ceived ox­y­to­cin went on trust­ing their treach­er­ous part­ners. Play­ers who had re­ceived an in­ac­tive spray in­stead of ox­y­to­cin did not.

Ox­y­to­cin was al­so found to re­duce ac­ti­vity in two brain re­gions: the amyg­da­la, which pro­cesses fear, dan­ger and pos­sibly risk of so­cial be­tray­al; and an ar­ea of the stria­tum, part of the cir­cuit­ry that guides and ad­justs fu­ture be­hav­ior based on re­ward feed­back.

These ox­y­to­cin-as­so­ci­at­ed changes, re­search­ers said, oc­curred only when play­ers be­lieved an ac­tu­al per­son was mak­ing the de­ci­sions about their mon­ey. The changes did­n’t oc­cur in a sep­a­rate “risk game,” where sub­jects were told a com­put­er would ran­domly de­cide wheth­er their mon­ey would be re­paid or not.

Play­ers’ brains were scanned us­ing func­tion­al mag­net­ic res­o­nance im­ag­ing, or fMRI, a tech­nique in which harm­less mag­net­ic fields and ra­dio waves are used to mon­i­tor brain ac­ti­vity by map­ping blood flow in the organ.

“Our in­sights in­to the neu­ral cir­cuit­ry of trust adapta­t­ion, and ox­y­to­cin’s role in trust adapta­t­ion, may al­so con­trib­ute to a deeper un­der­stand­ing of men­tal dis­or­ders such as so­cial pho­bia or au­tism that are as­so­ci­at­ed with so­cial deficits,” the re­search­ers wrote. “In par­tic­u­lar, so­cial pho­bia (which is the third most com­mon men­tal health dis­or­der) is char­ac­ter­ized by per­sist­ent fear and avoid­ance of so­cial in­ter­ac­tions.”

The work “has sig­nif­i­cant im­plica­t­ions for un­der­stand­ing men­tal dis­or­ders where deficits in so­cial be­hav­ior are ob­served,” wrote psy­cholo­g­ist Mauri­cio Del­ga­do of Rut­gers Uni­ver­s­ity in New Jer­sey, who was not in­volved in the re­search, in a pre­view in the same is­sue of the jour­nal. Fear of be­trayal, for ex­am­ple, “could serve as a pre­cur­sor to so­cial pho­bia,” he con­tin­ued, adding that the ox­y­to­cin find­ing sug­gests “po­ten­tial clin­i­cal ap­plica­t­ions.”

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